Certain New Chemicals or Significant New Uses; Statements of Findings – January 2026

The U.S. Environmental Protection Agency (EPA) published this Federal Register notice pursuant to the Toxic Substances Control Act (TSCA), summarizing its findings on new chemical and significant new use submissions reviewed during January 1–31, 2026. Under TSCA, manufacturers and processors must notify EPA before introducing new chemical substances into commerce or before commencing a significant new use of an existing chemical. For each submission reviewed — including Premanufacture Notices (PMNs), Microbial Commercial Activity Notices (MCANs), and Significant New Use Notices (SNUNs) — EPA determined that the substance or new use is 'not likely to present an unreasonable risk of injury to health or the environment.' This is the statutory threshold required before EPA can issue a 'not likely to present unreasonable risk' finding. Publishing these findings in the Federal Register serves as the official public record of EPA's determinations and allows affected parties, manufacturers, and the public to track which new chemicals have been cleared for commercial activity. Companies whose submissions received a favorable finding may proceed with manufacture, import, or use subject to any conditions EPA may have attached. This notice is part of EPA's routine monthly publication cycle under TSCA Section 5, ensuring transparency and regulatory accountability in the review of new chemical substances entering the U.S. marketplace.

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